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. 2019 Oct 22;2019(10):CD005015. doi: 10.1002/14651858.CD005015.pub4

Torregrosa 2007.

Methods
  • Study design: open‐label, parallel RCT

  • Duration of study: not reported

  • Duration of follow‐up: 12 months

Participants
  • Country: Spain

  • Setting: Single centre

  • Inclusion criteria: kidney transplant recipients aged 18 to 70 years, SCr < 221 µmol/L; iPTH > 60 pg/mL; BMD T‐score < ‐1

  • Number: treatment group (39); control group (35)

  • Mean age ± SD (years): treatment group (58 ± 9); control group (55 ± 8)

  • Sex (M/F): treatment group (20/19); control group (22/23)

  • Exclusion criteria: DM

Interventions Treatment group
  • Risedronate (oral): 35 mg/week


Control group
  • No treatment


Co‐interventions
  • Calcium carbonate: 2500 mg/d

  • vitamin D3: 800 IU/d

Outcomes
  • Change in BMD at lumbar spine and femoral neck from months 6 to 12

Notes
  • Funding source: not reported

  • Trial registration: not reported

Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Insufficient information to permit judgement
Allocation concealment (selection bias) Unclear risk Insufficient information to permit judgement
Blinding of participants and personnel (performance bias) 
 All outcomes High risk Unblinded
Blinding of outcome assessment (detection bias) 
 All outcomes Unclear risk Insufficient information to permit judgement
Incomplete outcome data (attrition bias) 
 All outcomes Unclear risk Insufficient information to permit judgement
Selective reporting (reporting bias) High risk Adverse events not reported systematically
Other bias Low risk No additional threats to validity identified