FIG 6.

Significant enhancement of arginine and histidine metabolic pathways. (A) Arginine deiminase and pyrimidine nucleotide de novo synthesis pathways. (B) Histidine degradation and purine nucleotide de novo biosynthesis pathways. (C to F) Glutamine (C), isoleucine (D), serine (E), and asparagine (F) degradation pathways. Pathways for S. pyogenes MGAS5005 were constructed based on the BioCyc database. Metabolite names are written in black and gene names in red. Log₂ fold changes of the 24-h (left), 48-h (center), and 96-h (right) groups with respect to the THY group are indicated in color scale boxes. Color scale indicates enrichment (red) and depletion (blue) during infection. An asterisk indicates significant difference: *, P < 0.1.