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. 2019 Oct 16;85(21):e01428-19. doi: 10.1128/AEM.01428-19

TABLE 2.

Expression levels of selected genes/operons/regulon

Gene category and SP5448 number Gene namea Encoded function(s) Log2 fold changeb
24 h 48 h 96 h
Virulence factors
    870 nga NAD glycohydrolase 5.05* 5.79* 5.49*
    880 slo Pore-forming cytotoxin 4.80* 5.67* 5.35*
    1845 endoS Immunoglobulin-modifying protein 3.91* 5.10* 4.66*
    2470 sda1 Streptococcal nuclease D 4.08* 5.30* 4.93*
    3755 spd3 Streptococcal extracellular nuclease 3 5.11* 6.27* 5.70*
    4075 grab Macroglobulin-binding protein −4.11* −5.43* −5.32*
    1702 speA Superantigen 1.11* 1.80* 2.23*
    6700–6740 sagABCDEFGHI Secreted cytotoxin 4.69* 5.76* 5.62*
    7800 spyCEP IL-8-degrading protease 4.12* 5.37* 5.71*
    8645 smeZ Superantigen 1.24* 1.20* 1.25*
    8690 lbp Laminin-binding surface protein 6.56* 6.13* 7.04*
    8710–8730 fbaA, scpA, sic, emm Mga virulence regulon 2.00* 2.94* 3.54*
    8800 speB Streptococcal cysteine protease 10.09* 9.38* 10.11*
    8820 spd Streptococcal nuclease B 7.06* 7.80* 7.74*
    9365–9375 hasABC Hyaluronic acid capsule biosynthesis 0.79 1.08* 1.39*
Carbohydrate utilization
    1210–1240 nanH Sialic acid production and catabolism 3.84* 3.84* 4.08*
    1830–1855 pmi, scrK, endoS, scrAB Sucrose transport and catabolism 1.94* 3.12 2.23
    2540–2570 lacABD Galactose transport and catabolism 3.53* 3.27* 3.83*
    4190–4210 Cellobiose transport 2.64* 3.47* 3.54*
    4275–4305 malACDX, amyAB Cyclodextrin transport and catabolism 4.29* 6.23* 5.74*
    5660–5675 ptsABCD Mannose/fructose/sorbose transport 2.67* 2.37* 2.84*
    8320–8350 lacABDEFG, lacC.2 Lactose transport and catabolism 2.95* 2.39* 3.81*
Amino acid utilization
    3210–3235 arcABCD Arginine catabolism 5.88* 5.67* 5.84*
    8955–8995 hutDGHIU, ftcD, fchA, fhs.2 Histidine catabolism 6.38* 7.22* 7.27*
Peptide transport
    1400–1420 oppABCDF Oligopeptide transporter 0.69 0.88* 0.62
    8655–8675 dppABCDF Dipeptide permease 1.79* 1.93* 2.78*
Oxidative stress response
    3280 dpr DNA protection during starvation protein −0.86 −0.44 −1.19
    3875 sodA Superoxide dismutase −2.58* −2.07* −3.12*
    7040 gpoA Glutathione peroxidase −1.40* −1.32* −1.19*
    8945 ahpC Alkyl hydroperoxide reductase −0.64 −0.33 0.31
Trace metal transport
    560–570 adcRCB Zinc transport 1.86* 1.87* 2.29*
    1895–1920 shr, shp, siaABCD Iron and manganese transport 3.73* 4.11* 4.29*
    2520–2530 copZAY Copper transport 1.18* 0.23 1.93*
    7665–7675 mtsABC Iron and manganese transport 0.56 0.72 0.18
    7885–7900 fhuGBDA Iron and manganese transport 1.97* 2.06* 1.64*
    8685–8690 htpA, lbp Zinc transport 6.48* 6.14* 6.97*
Sodium and proton transport
    805–840 ntpABCDEFKI V1-V0 (V)-ATPase transport system 3.11* 4.49* 4.67*
    6640–6675 atpABCDEFGH F1-F0 (F)-ATPase transport system −0.97 −1.14* −1.38*
a

Only gene names annotated by PATRIC are shown.

b

The expression values of 24-h, 48-h, and 96-h groups relative to those of the THY group are shown. Log2 fold changes of operons or regulons are shown as mean log2 fold changes in transcript levels for all genes. An asterisk indicates significant difference: *, P < 0.1. In operons or regulons, asterisks indicate that a significant difference was confirmed for all included genes.