FIG 2.

HIF-1α and VEGF-A display similar kinetics of expression following L. major infection. C57BL/6 mice were infected with L. major parasites in the ear dermis, and ears were analyzed by quantitative real-time PCR at 3, 7, 14, and 35 days p.i. for the expression of HIF-1α (A) and VEGF-A (B). Relative mRNA expression normalized to that of the RPS11 housekeeping gene is presented as the mean value + SEM for 5 mice per group from one experiment. *, P < 0.05, **, P < 0.01, and ***, P < 0.001, by Dunnett’s test for multiple comparisons.