FIG 3.

Fibrosis development in AIEC-colonized Il10^−/− mice recapitulates histopathological features of fibrosis in human Crohn’s disease. (A) Representative colonic histology of ΔfyuA mutant-colonized fibrotic Il10^−/− mice. (B and C) Representative histology of full-thickness colon cross sections from fibrotic Crohn’s disease patients, representative of 3 per group. (C) Magnification of the muscularis serosa. Colon sections were stained with H&E or Sirius red. Regions of Sirius red binding are indicated with white arrowheads. F, fibrotic lesion. Scale bars, 100 μm.