Fig. 1.

The p73 gene and its knockout phenotypes. The p73 locus encodes two classes of isoforms. The P1 promoter yields TAp73 variants containing the transactivation (TA) domain. The P2 promoter yields N-terminally truncated variants (deltaN, DNp73). DNA-binding domain (DBD), oligomerization domain (OD) and sterile alpha motif domain (SAM) are shared. C-terminal splice variants generate alternate β, γ and δ isoforms of the TA and DN classes. Global (p73KO) and isoform-specific knockout mice (TAp73KO and DNp73KO) were generated by deleting the indicated exons. They exhibit distinct developmental phenotypes that also differ in severity as discussed in the main text.