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JmjC-containing histone demethylase functions in ESCs. JMJD2A/C predominantly demethylate H3K9me3/2, whereas JMJD1A/B demethylate H3K9me2/1 at H3K4me3-positive domains, which are enriched at promoters. Both JMJD clusters are required for pluripotency gene expression in ESCs.
