Fig. 3.

Comparison of BAF genomic binding in different cell types. Summit-centered heatmap of BRG1 (SMARCA4) ChIP-seq data illustrating the binding of BRG1 to chromatin in four different human cell types. A simple schematic of a ChIP-seq workflow is also included on the left side of the heatmap. Darker shade of blue indicates enrichment of BRG1 binding. The heatmap is clustered into five groups according to K-means. Groups I-IV demonstrate BRG1-binding sites that are highly specific to the individual cell types, while group V represents BRG1-binding sites that are shared among multiple cell types. The raw data were acquired from previously published studies (Abraham et al., 2013; Bao et al., 2015; Barutcu et al., 2016; Rada-Iglesias et al., 2011) and were normalized based on sequencing depth.