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. 2019 Oct 15;10:2430. doi: 10.3389/fimmu.2019.02430

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Copyright © 2019 Liu, Ou, Shen, Qiu, Zhang, Zhang, Shao, Gao and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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BATF silencing enhanced PPD-specific CD4⁺ T cells proliferation in patients with ATB in vitro. (A) Representative CD4-gated dot plots (left panel) and histograms (right panel) of proliferation of CFSE-labeled cells were measured by the fraction of CFSE^dimCD4⁺ cells in the presence of PPD for 4 days after transfection. (B) PPD-specific CD4⁺ T cells proliferation in the BATF siRNA group was markedly higher than that in the negative control siRNA group (n = 6). Data are expressed as before-and-after plots. ^**P < 0.01. PPD, purified protein derivative; ATB, active tuberculosis; siRNA, small interfering RNA.