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. 2019 Oct 15;13:1016. doi: 10.3389/fnins.2019.01016

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Copyright © 2019 Sofat, Ejindu, Heron, Harrison, Koushesh, Assi, Kuttapitiya, Whitley and Howe.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Regression analyses of clinical, biochemical, and structural parameters in knee OA. (A,B) Multivariable regression analyses were conducted for continuous variables including VAS, WOMAC pain, urinary CTX-II, MOAKS-defined damage including bone marrow lesion load (BML_Load), total synovitis (total_Syn), cartilage degradation load (CD_Load), osteophyte load (Ost_Load), pain pressure thresholds (PPT), and Hospital Anxiety and Depression Scale (HADS). Regression analysis is shown for the urinary type II collagen degradation product biomarker (CTX-II) in relation to structural damage by osteophytes and synovitis. Covariates were BMI and age in the analysis. Analyses are presented with p-values, coefficients, and standard error. There were 78 degrees of freedom.