Table 1.
DC subsets in mouse and human: phenotype, localization, and function.
| Human DC subsets | Phenotype | Location | Function |
|---|---|---|---|
| Plasmacytoid DC | CD123 CD303/BDCA-2 CD304/BDCA-4 |
Blood, tonsil, non-lymphoid tissues | Production of type I and III IFN |
| Myeloid cDC1 | CD141/BDCA-3 | Blood, tissues, and lymphoid organs | Present Ag to CD8+T cells and produce type III IFN |
| Myeloid cDC2 | CD1c/BDCA-1 CD2 CD11c CD11b |
Blood, tissues and lymphoid organs | Activate Th1/Th2/Th17 and CD8+T cells |
| Langerhans cells | CD207 CD1a E-Cadherin |
Skin (epidermis) | Transfer Ag to afferent lymphatics, stimulate CD8+T cells |
| Mo-DC | CD11c CD1c/BDCA-1 CD1a |
Ex vivo-generated | |
| Murine DC subsets | |||
| Plasmacytoid DC | CD11cint CD11b− CD8−B220+Gr-1+ |
Lymphatic and non-lymphoid tissue | IFN-α production |
| CD8+ cDC | CD11c+ CD11b−CD8+ CD24+ MR+ |
Lymphatic and non-lymphoid tissue | Activate CD4+ and CD8+ T cells, Ag presentation |
| CD8− cDC | CD11c+ CD11b+CD8− CD24− |
All tissues | Activate CD4+ T cells, transport Ag to LN |
| Langerhans cell | CD11c+ CD11b+ CD8−Langerin+ CD1a+ |
Skin (epidermis) | Transport Ag from skin to LN |
CD, cluster of differentiation; cDC, conventional DC; DC, dendritic cell; Mo-DC, monocyte-derived DC; pDC, plasmacytoid DC; LN, lymph nodes; MR, mannose receptor; IFN, interferon.