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. 2019 Oct 15;10:2350. doi: 10.3389/fmicb.2019.02350

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Copyright © 2019 Yang, Rajeeve, Rudel and Dandekar.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pathway activity changes of central metabolism in Ct during infection. EB flux changes are given by a red solid line and RB flux changes are shown as green solid line; the average flux change during infection (combining EB and RB as present during infection in the host cells) is given as black dashed line. The time course indicates the variation over infection from 20 hpi, 40 hpi and several hours (about 8 h) later after 40 hpi respectively. Flux intensities are normalized between zero and one (fully active). (A) pentose phosphate pathway (PPP); (B) glycolysis and glycerophospholipid metabolism (EMP/GPL); (C) a cyclic pathway formed by 6-phosphofructokinase 1 and diphosphate-fructose-6-phosphate 1-phosphotransferase (pfkA); (D) tricarboxylic acid cycle (TCA); (E,F) fatty acid biosynthesis (FA1) and (FA2); and (G) gluconeogenesis (GNG).