Table 1.
Summary of TCR and antibody CDR structural clusters.
| TCR-only | TCR and antibody | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| α1 | α2 | α3 | β1 | β2 | α1/L1 | α2/L2 | α3/L3 | β1/H1 | β2/H2 | |
| # Sequences | 356 | 329 | 338 | 357 | 360 | 2817 | 3168 | 3210 | 3404 | 3328 |
| # Unique sequences | 45 | 44 | 99 | 33 | 39 | 625 | 242 | 954 | 826 | 924 |
| Sequence lengths observed | 5-8 | 5-8 | 8-15 | 5-6 | 5-7 | 5-8/3-12 | 5-8/2-7 | 8-15/5-14 | 5-6/4-15 | 5-7/6-12 |
| # Canonical classes | 7 | 7 | 5 | 1 | 2 | 13 | 3 | 11 | 9 | 7 |
| # Pseudo-classes | 3 | 3 | 11 | 1 | 1 | 15 | 14 | 36 | 23 | 17 |
| # Sequences in canonical classes | 318 | 248 | 126 | 344 | 340 | 2317 | 2856 | 2471 | 2868 | 2759 |
| # Sequences in pseudo-classes | 18 | 56 | 74 | 5 | 6 | 299 | 270 | 341 | 205 | 176 |
| # Unclustered sequences | 20 | 25 | 138 | 8 | 14 | 201 | 42 | 398 | 331 | 393 |
“#” refers to the number of entities. TCR-only clusters are formed at a threshold of 1.0Å; TCR and antibody CDRs are clustered using the standard threshold for antibody CDRs given in Nowak et al. (20). The TCR and antibody CDR sequence lengths observed in the combined TCR and antibody CDR cluster are separated by '‘/”.