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. 2019 Oct 15;10:2432. doi: 10.3389/fimmu.2019.02432

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Copyright © 2019 Hara, Sasaki, Satoh-Takayama, Kanaya, Kato, Takikawa, Takahashi, Tachibana, Kim, Surh and Ohno.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The elimination of dietary antigens decreases IgA production in the SI. (A) IgA concentration in feces from GF (n = 9) and GF-AF mice (n = 10). (B) Representative flow cytometry plots of IgA vs. B220 on CD3⁻ lymphocytes of SI-LP and LI-LP of GF and GF-AF mice (left), and the absolute numbers of B220⁻IgA⁺ IgA-producing plasma cells (right). Data are pooled from at least three independent experiments and are presented as mean ± SD. Welch's t-test was used for statistical analysis. *p < 0.05, ***p < 0.001.