Figure 5.

Antibody-dependent NK cell activation in MS patients and controls. (A) Experimental design evaluating NK cell degranulation (CD107) and intracellular TNFα production in functional experiments using 721.221 lymphoblastoid cell lines as NK cell targets. (B) CD107 expression and TNFα production by CD56^dim and CD56^bright NK cells in controls and MS patients. (C) CD107 expression and TNFα production by CD56^dim NK cells in controls and MS patients according to clinical form. PBMC: peripheral blood mononuclear cells. Controls, n = 17; MS patients, n = 42 (RRMS, 22; SPMS, 8, PPMS 12). P-values (Mann–Whitney U-test for CD107 and Student's t-test for TNFα expression): * <0.05, ** <0.01, *** <0.001, **** <0.0001.