Table 4.

C. americana extract, partition, and fraction growth inhibition (IC₅₀ and MIC) and HaCat cytotoxicity IC₅₀ values (in µg ml^{− 1}).

		649	649C	649C-F8	649C-F9	649C-F12	649C-F13	649C-F14	649C-F15	649C-F17	649C-F19	649C-F21	649C-F22	Cli-
IC50 for C. acnes growth	ATCC6919	32	32	16	8	16	16	16	16	16	16	16	16	0.0625
	B104.1	64	16	32	16	32	8	8	8	32	32	32	32	>4
	B104.2	64	32	32	32	32	8	16	16	32	32	32	32	>4
	B104.4	64	16	64	8	32	8	16	16	32	32	32	32	>4
	B104.5	32	16	32	16	32	4	8	8	32	32	32	32	>4
	B104.6	64	32	64	16	64	16	32	32	64	64	64	64	0.5
	B104.7	>64	64	64	16	64	16	64	64	>64	64	64	64	0.5
	B104.8	64	16	32	8	32	8	16	16	32	32	32	32	>4
	EU-09	>64	32	64	16	64	16	32	32	64	64	64	32	>4
	EU-16	64	32	32	16	32	8	16	8	8	8	16	16	< 0.125
MIC for C. acnes growth	ATCC6919	>32	>32	32	16	16	16	32	32	16	16	16	16	>8
	B104.1	64	32	64	32	64	16	32	32	64	64	64	64	>4
	B104.2	64	32	64	32	64	16	64	32	64	64	64	64	>4
	B104.4	64	32	64	16	64	16	64	32	64	64	64	64	>4
	B104.5	64	32	64	32	64	16	32	32	64	64	64	32	>4
	B104.6	64	32	>64	16	64	16	64	64	>64	64	64	64	0.5
	B104.7	>64	64	>64	16	64	32	64	64	>64	64	64	64	1
	B104.8	>64	32	64	16	64	16	32	32	64	64	64	32	>4
	EU-09	>64	64	>64	16	64	16	64	64	>64	64	64	64	>4
	EU-16	>64	64	32	16	64	16	64	32	32	16	32	16	0.125
HaCat	IC 50	> 1024	> 1024	128	256	>512	>512	> 1024	> 512	512	>512	>512	1024	–
TI	Lower range	16	32	2	8	8	32	16	8	8	8	8	16	–
	Upper range	>32	>64	8	32	32	128	128	64	64	64	32	64	–

All values were determined as compared to the vehicle control for at least three replicates. The therapeutic index (TI) is reported as a range of values for the 10 C. acnes isolates (cytotoxicity IC₅₀ divided by growth inhibition IC₅₀).

Cli clindamycin, antibiotic control.