Table 2.
Significant pathways with related pathogenic genes and predicted genes.
| Significant Pathways | 20 Pathogenic Genes and 18 Interacted Genes | P value |
|---|---|---|
| Epithelial to mesenchymal transition in colorectal cancer | COL4A6, WNT8B, SPARC, WNT1 | 0.00083567 |
| Focal Adhesion-PI3K-Akt-mTOR-signaling pathway | COL4A6, COL5A2, COL1A1, COL1A2, CREB3L1 | 0.0010862 |
| miR-509-3p alteration of YAP1/ECM axis | COL1A1, SPARC | 0.0011611 |
| Focal Adhesion | COL4A6, COL5A2, COL1A1, COL1A2 | 0.0018166 |
| Inflammatory Response Pathway | COL1A1, COL1A2 | 0.0035058 |
| miRNA targets in ECM and membrane receptors | COL5A2, COL1A2 | 0.0059006 |
| PI3K-Akt Signaling Pathway | COL4A6, COL1A1, COL1A2, CREB3L1 | 0.012283 |
| Sterol Regulatory Element-Binding Proteins (SREBP) signaling | MBTPS2, SEC24D | 0.01637 |
| Hypothetical Craniofacial Development Pathway | WNT1 | 0.021586 |
| ncRNAs involved in Wnt signaling in hepatocellular carcinoma | SERPINF1, WNT1 | 0.023282 |
| LncRNA involvement in canonical Wnt signaling and colorectal cancer | SERPINF1, WNT1 | 0.031757 |
| Senescence and Autophagy in Cancer | COL1A1, SPARC | 0.034042 |
| EDA Signaling in Hair Follicle Development | BMP1 | 0.037488 |
| Osteoblast Signaling | COL1A1 | 0.037488 |
| Wnt Signaling Pathway | SERPINF1, WNT1 | 0.040029 |
| Canonical and Non-Canonical TGF-B signaling | BMP1 | 0.045347 |
| Regulation of Wnt/B-catenin Signaling by Small Molecule Compounds | WNT1 | 0.047953 |
| Adipogenesis | BMP1, WNT1 | 0.04837 |
Eighteen significant pathways (P < 0.05) were identified with 20 OI causative genes and their 18 interacting gene partners from protein–protein interaction network. Candidate genes (the predicted gene set B) are represented in bold font.