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LC50 of ruxolitinib in cells surviving multiple exposure to 1.5 × LC50 concentrations of ruxolitinib. Cells were exposed to the specified concentration for total of five exposures. The LC50 of drug in corresponding surviving cell populations was calculated similarly to naïve cells, and the values are summarized in the corresponding table. We were unable to collect survivors after the first exposure of AU565 cells to ruxolitinib at these concentrations.
