Table 3.

Results from regression analyses showing associations to outcomes (NIHSS and mRS) in the substudy assessing 7-year outcomes

	NIHSS at 7 years		mRS > 2 at 7 years
	β	95% CI for β	OR	95% CI for OR
Log sNfL 3 months	3.82	3.11–4.53	5.55	3.31–9.29
Log sNfL 3 monthsa	3.77	3.03–4.50	6.61	3.45–10.89
Log sNfL 3 monthsb	1.76	0.91–2.60	2.86	1.45–5.65
NIHSS score baseline	0.42	0.36–0.49	1.18	1.12–1.24
NIHSS score baselinec	0.42	0.36–0.49	1.20	1.14–1.27
NIHSS score baselined	0.31	0.23–0.39	1.13	1.06–1.20

Multivariable linear regression models were used for calculation of β, i.e., change in NIHSS at 7 years, per log unit increase in sNfL (one log unit represents a tenfold increase). Multivariable logistic regression models were used for calculation of odds ratio per log unit increase in sNfL for poor outcome (mRS > 2) at 7 years. For 7-year mRS 3-month sNfL was available in 320 cases and for 7-year NIHSS in 272 cases

^aAdjusted for age, history of stroke, and day for blood sampling at 3-month follow-up

^bAdjusted for age, history of stroke, day for blood sampling at 3-month follow-up, and baseline NIHSS

^cAdjusted for age and history of stroke

^dAdjusted for age, history of stroke, 3-month log sNfL and day for blood sampling at 3-month follow-up