Table 1.
Carbon-ion irradiation | α (Gy-1) | β (Gy-2) | R 2 | DSF10 (Gy) | SERSF10 | |
---|---|---|---|---|---|---|
A549 | Control | 0.665 | 0.993 | 3.46 | ||
0.5 μg/mL Gd | 0.575 | 0.996 | 3.99 | 0.847 | ||
5.0 μg/mL Gd | 0.625 | 0.96 | 3.68 | 0.954 | ||
10.0 μg/mL Gd | 0.738 | 0.996 | 3.11 | 1.10 | ||
NH1299 | Control | 0.393 | 0.084 | 0.999 | 3.39 | |
0.5 μg/mL Gd | 0.73 | 0 | 0.95 | 3.15 | 1.07 | |
5.0 μg/mL Gd | 0.76 | 0 | 0.98 | 3.01 | 1.11 | |
10.0 μg/mL Gd | 0.247 | 0.09 | 0.987 | 3.65 | 0.933 | |
NH1650 | Control | 1.06 | 0.073 | 0.999 | 1.99 | |
0.5 μg/mL Gd | 1.24 | 0.991 | 1.93 | 1.03 | ||
5.0 μg/mL Gd | 1.44 | 0.999 | 1.60 | 1.20 | ||
10.0 μg/mL Gd | 1.45 | 0.996 | 1.60 | 1.20 |
Coefficients α, β, and R2 are fitting parameters using the linear-quadratic model; DSF10 means the dosage of carbon ion irradiation at 10% cell survival fraction; SERSF10 means sensitizer enhancement ratios of irradiated NSCLC cells at 10% cell fraction