. 2019 Feb 22;27(11):4145–4154. doi: 10.1007/s00520-019-04700-9

Table 2.

EORTC mean scores of sample, compared to reference data [27]

	Reference data (n = 1722); head and neck cancer stage III–IV, mean (SD)	Baseline scores patients (n = 56)	p value
QLQ-C30
Global health-related QoL	63.1 (22.4)	73.3 (19.7)	< 0.001^a
Physical functioning	81.2 (20.2)	87.0 (14.0)	0.004
Role functioning	78.8 (27.9)	72.2 (29.8)	0.111
Emotional functioning	71.2 (24.1)	78.2 (17.5)	0.005
Cognitive functioning	86.4 (19.1)	89.8 (19.3)	0.198
Social functioning	82.2 (24.7)	77.8 (25.5)	0.208
Fatigue	27.6 (25)	21.8 (20.2)	0.04
Nausea and vomiting	5.2 (13.3)	1.9 (7.0)	0.001
Pain	24.9 (26.3)	21.6 (26.4)	0.364
Dyspnea	18.0 (26.6)	6.9 (16.5)	< 0.001^a
Insomnia	28.5 (32.4)	26.5 (29.2)	0.625
Appetite loss	19.4 (29.3)	8.6 (20.7)	< 0.001^a
Constipation	11.7 (23.2)	8.0 (18.2)	0.145
Diarrhea	6.1 (16.7)	4.3 (13.0)	0.32
Financial difficulties	18.8 (30.2)	13.2 (13.0)	0.106
QLQ-HN-35
Pain	29.9 (25.1)	21.3 (19.1)	0.002
Swallowing	27.5 (26.1)	17.8 (23.8)	0.005
Senses	20.0 (30.0)	9.8 (17.1)	< 0.001^a
Speech	27.1 (27.2)	16.9 (19.7)	< 0.001^a
Social eating	23.9 (26.7)	13.0 (14.4)	< 0.001^a
Social contact	13.2 (19.1)	7.7 (13.0)	0.004
Sexuality	32.3 (36.1)	28.1 (21.8)	0.31
Teeth	27.8 (35.0)	10.2 (21.7)	< 0.001^a
Opening mouth	22.4 (31.9)	30.1 (33.2)	0.099
Dry mouth	31.1 (34.2)	19.2 (23.2)	0.001^a
Sticky saliva	32.4 (35.4)	20.9 (24.0)	0.001^a
Coughing	34.9 (32.1)	17.7 (26.1)	< 0.001^a
Felt ill	21.7 (29.2)	10.3 (19.3)	< 0.001^a
Pain killers	52.8 (49.9)	61.5 (49.1)	0.205
Nutritional supplements	27.0 (44.4)	28.9 (45.7)	0.772
Feeding tube	18.3 (38.7)	7.6 (26.7)	0.005^a
Weight loss	41.3 (49.2)	34.6 (48.0)	0.32
Weight gain	25.9 (43.8)	36.5 (48.6)	0.121

^aStatistically significant difference