Fig. 4. Social interaction is decreased by selective regional knock down of somatostatin (SST) expression in the ventral hippocampus (vHipp) and not by parvalbumin (PV) in male and female rats combined.

a. Subpopulations of male b and female c rats were also affected by only SST expression knock down in the vHipp, and not by PV expression knockdown of this region. In the medial prefrontal cortex (mPFC), both PV and SST expression knock down results in a significant decrease in the time spent interacting in mixed population (males and females, d). The same behavioral pattern is observed in a male only population e; however, female rats are only affected by selective regional knockdown of SST, and not PV expression in the mPFC f. n = 6–18 rats per group. *P < 0.05