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. 2019 Oct 21;9:15077. doi: 10.1038/s41598-019-51249-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Simulated macrophage population fractions. Time evolution of macrophage subtype populations for (A) primary tumor on control ECM, (B) metastatic tumor on control ECM, (C) primary tumor on transitional ECM, and (D) metastatic tumor on transitional ECM. Primary tumor simulations of either ECM construct exhibited more balanced proportion of M1:M2 macrophage subtypes than metastatic tumors; on either ECM construct, M2 macrophages were more prominent than M1 for primary tumors. In contrast, M1 macrophages dominated for the metastatic tumors.