. 2019 Oct 21;9:15077. doi: 10.1038/s41598-019-51249-y

Table 1.

Model conditions for simulation experiments.

Simulations		Case 1	Case 2	Case 3	Case 4
With naïve macrophages	ECM	cECM	tECM	cECM	tECM
With naïve macrophages	Tumor Type	Primary	Primary	Metastatic	Metastatic
With polarized macrophages	ECM	cECM	tECM	cECM	tECM
With polarized macrophages	Tumor Type	Primary	Primary	Metastatic	Metastatic

Simulation cases with naïve macrophages assess tumor response to differential ECM composition. Cases with polarized macrophages explore the response to heterogeneous macrophage populations. cECM: control (normal) ECM; tECM: transitional ECM.