Fig. 6.

Change in genetic effect as a function of aging and exposure to statins. We derived for the top variant of each of the 13 core regulator genes we identified, a the interaction effect with statin, and b the effect on ${\mathrm{\Delta }}_{\mathrm{bf}}$, the difference in the metabolite measurement between the two time points. In all association tests, the allele associated with an increase level of metabolite in the marginal test at baseline measurement was defined as the coded allele. Non-significant test are in pink, test nominally significant are in red, and test significant at 5 × 10⁻³ are in dark red. In agreement with the heritability analysis most of the coefficients for ${\mathrm{\Delta }}_{\mathrm{bf}}$ are negative, indicating an overall decrease of genetic effect. Two genes, APOC1 and TRIB1, show strong enrichment for interaction with statin