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. 2019 Oct 21;9:15034. doi: 10.1038/s41598-019-51018-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Methylation and genetic landscape of the representative hypermethylated SE: chr12:52622299−52631702 in JHU cohort. (A) Genomic landscape of the SE region and potential target genes within one Mbp of the SE. (B) Relative average methylation coverage across the SE region (red – tumor, black – normal). (C) Log-transformed RNA expression of the potential target genes (z-score). (D) Kendall-tau values and corresponding FDR for correlation of promoter methylation with gene expression, as well as SE region methylation with gene expression of target genes.