Figure 2. . Inhibition of protein aggregation.

The effect of Y220C mutant stabilizers on the rate of aggregation of the mutant protein was measured at 37°C by monitoring light scattering at 500 nm. (A) Concentration-dependence of aggregation inhibition by PK9318. (B) Aggregation of the Y220C mutant at 15 μM PK9318 (green), PK9327 (red) or PK9328 (orange), and without compound (black).