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. 2019 Oct 21;11(19):2491–2504. doi: 10.4155/fmc-2019-0181

Figure 3. . Structures of p53-Y220C with subsite 2-targeting carbazole derivatives.

Figure 3. 

(A) Structure of the Y220C mutant bound to PK9284 (Protein Data Bank [PDB] ID 6GGA). The protein is shown as a gray surface representation, with the sulfur of Cys220 highlighted in yellow. The ligand is shown as a stick model. (B) Structure of the Y220C-PK9318 complex (PDB ID 6GGB). A cross-section of the binding pocket is shown. (C) Superposition of the binding modes of PK083 (gray carbon atoms; PDB ID 2VUK), PK9318 (green carbon atoms; PDB ID 6GGB), PK9320 (pink carbon atoms; PDB ID 6GGC) and PK9324 (cyan carbon atoms; PDB ID 6GGD) upon binding to the Y220C mutant. (D) Structure of the Y220C-PK9320 complex (PDB ID 6GGC). Orientation and color codes are the same as in panel B. In all four panels, chain B of the asymmetric unit is shown.