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. 2019 Sep 26;24(19):3499. doi: 10.3390/molecules24193499

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Blood clearance profiles and biodistribution for naked NLC and RXP-NLC in C57BL/6 ApoE^-/- mice (n = 3 for NLC, n = 3 for RXP-NLC 5 mg injected per mouse). (a) Comparison of blood clearance rates between the two NLCs (naked NLC: Black circles, RXP-NLC: Empty triangles). Time expressed in minutes is reported in logarithm scale. (b) Biodistribution and fluorescence intensity patterns observed for the two NLCs in liver, spleen, kidneys, lungs, femur bone, and brain harvested 24 h after injection. Fluorescence is expressed as arbitrary units (AU) and reported in logarithm scale.