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Surface plasmon resonance (SPR) analyses of the binding affinities for imatinib of PPARγ WT LBD and PPARγ R288A mutant LBD. SPR sensorgrams for imatinib binding of PPARγ R288A mutant LBD (A) and PPARγ WT LBD (B) are shown. Sensorgrams show binding at increasing concentrations (0.625, 1.25, 2.50, 5.00, and 10.0 µM) of imatinib to immobilized PPARγ R288A mutant LBD and PPARγ WT LBD. The calculated Kd values are also shown.
