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. 2019 Sep 26;24(19):3502. doi: 10.3390/molecules24193502

Figure 2.

Figure 2

Structure and molecular weight of KYNA and of its derivatives (4, 5, 7, 8), respectively, together with their effects on the field excitatory postsynaptic potentials (fEPSPs) recorded in CA1 region of hippocampus. Control (c) was observed during the last 5 min of resting period, before administration of a compound (* in Figure 1A). Effect on the amplitudes of fEPSPs was observed during the last 5 min of wash-in periods, respectively (# in Figure 1A). Each slice was subjected to only one measurement. Changes in fEPSP amplitudes (mean ± SEM) due to application of KYNA or of its analogs are shown in the bar graphs. The numbers of measurements (N) are indicated in the columns; n.s. = p > 0.05; **p < 0.01; ***p < 0.001).