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. 2019 Sep 23;24(19):3447. doi: 10.3390/molecules24193447

Figure 4.

Figure 4

THQ interferes with the internalization step of ZIKV entry. (A) A549 cells were infected with ZIKVGFP at MOI of 1 for 1 h at 4°C in the presence of THQ (125 µg/mL), and then the temperature was shifted to 37 °C in absence of THQ. Epigallocatechin gallate, EGCG (100 µM), was used as positive control. (B) A549 cells were infected for 1h with ZIKVGFP at 4 °C, then the temperature was shifted to 37°C in presence of THQ. Isoquercitrin, Q3G (100 µM), was used as positive control. Flow cytometric analysis of GFP fluorescence was performed 24 h postinfection. The results shown are means ± SD of four independent experiments and are expressed as relative value compared to untreated infected cells. One-way ANOVA and Dunnett’s test were used for statistical analysis (*** p < 0.001; **** p < 0.0001; n.s = not significant).