Table 2.

Comparison of X-ray and electron nanocrystallography.

	X-Ray Nanocrystallography	Electron Nanocrystallography
Source/accessibility	Large Facilities/Less accessible	Laboratory Sources/Frequent accessibility
Sample consumption	Large to moderate with serial crystallography	Less
Radiation damage	Minimal with X-ray FEL	Large and limits the highest attainable resolution. However, can be overcome by merging a large number of low dose datasets
Room temperature studies	Possible with current technologies	Not possible with current technologies
Ultrafast Time resolved studies	Possible	Not possible
Sensitivity to ions and H-atom	Less sensitive	Highly sensitive