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. 2019 Sep 21;24(19):3427. doi: 10.3390/molecules24193427

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A) The level of prostacyclin (PGI₂) synthase mRNA increased significantly compared to the control after LPS-treatment indicated by *. # indicates the significant changes in PGI₂ synthase mRNA in LPS-induced inflammation and ACE₅₀ treatment compared to the level of PGI₂ synthase mRNA in LPS-induced inflammation without ACE₅₀. (B) The level of cyclooxygenase-1 (COX-1) mRNA increased significantly compared to the control after LPS-treatment indicated by *. # indicates the significant changes in COX-1 mRNA in LPS-induced inflammation and ACE₅₀ treatment compared to the level of COX-1 mRNA in LPS-induced inflammation without ACE₅₀. (C) The level of COX-2 mRNA increased significantly compared to the control after LPS-treatment indicated by *. # indicates the significant changes in COX-2 mRNA in LPS-induced inflammation and ACE₅₀ treatment compared to the level of COX-2 mRNA in LPS-induced inflammation without ACE₅₀. Results are expressed in the percentage of the control (100% is represented by the solid lines). Data are expressed as the mean ± SEM of four individual experiments. ACE₅₀, 50 μg/mL anthocyanin extract.