Figure 1.

Promutagenicity of oxidative DNA lesions. (A) Generation of oxidized purines by reactive oxygen species (ROS) and reactive halogen species (RXS). (B) Mutagenic base pairing between 8-oxoguanine and adenine, which involves two hydrogen bonds between a syn conformer of 8-oxo-dG and an anti-conformer of dA. This mutagenic base pair can cause G to T transversion mutations. (C) Potential mutagenic base pairing between a syn conformer of 8-chloro-dG and an anti-conformer of dG, which can lead to G to C transversion mutations.