Figure 18.

(A) Schematic view of 15 nm CoFe₂O₄/MnFe₂O₄ core/shell MNPs and its SAR value in comparison with the values for its components (9 nm CoFe₂O₄ and 15 nm MnFe₂O₄). (B) SAR values of single-component magnetic NPs and (C) the various of SAR values of combinations of core–shell NPs. (D) Plot of tumor volume (V/V_initial) versus days after hyperthermia treatment with the single-component and core–shell NPs. In the group treated with core–shell MNPs-based hyperthermia, the tumor was completely eliminated in 18 days. (E) Nude mice xenografted with cancer cells (U87MG) before treatment (upper row, dotted circle) and 18 days after treatment (lower row) with untreated control, CoFe₂O₄@MnFe₂O₄-based hyperthermia, Feridex-based hyperthermia and doxorubicin, respectively [31].