Table 2.

Associations Between Plasma Metabolite Levels and Incidence of T2DM in the MPP (N = 698) and the MDC-CC (N = 3423)

	MPP (N = 698)		MDC-CC (N = 3423)
Metabolite	OR	P	HR	P
DMGU	1.94 (1.57–2.39)	4.9e-10	1.63 (1.35–1.98)	3.2e-7
7MG	1.65 (1.35–2.01)	1.2e-6	1.49 (1.22–1.83)	1.1e-4
Kynurenate	2.10 (1.49–2.97)	2.3e-5	1.31 (1.16–1.48)	1.1e-5
HTML	2.02 (1.45–2.82)	3.1e-5	1.50 (1.19–1.87)	5.1e-4
Beta-carotene	0.60 (0.45–0.78)	1.8e-4	0.68 (0.60–0.78)	2.3e-8
N-Acetylcarnosine	1.48 (1.20–1.82)	2.2e-4	1.27 (1.11–1.45)	4.7e-4
TML	1.35 (1.14–1.60)	4.2e-4	1.20 (1.07–1.34)	2.0e-3
Creatinine	1.35 (1.11–1.63)	2.2e-3	1.07 (0.94–1.21)	0.28
Hypoxanthine	1.73 (1.18–2.54)	4.7e-3	1.24 (1.11–1.38)	1.5e-4
Pantothenate	1.27 (1.07–1.49)	5.0e-3	1.13 (1.01–1.27)	0.027
Urea	1.27 (1.07–1.51)	6.1e-3	1.18 (1.06–1.31)	2.7e-3

ORs and HRs are expressed per SD increment of plasma metabolite and calculated from logistic regression models. Regression models are adjusted for age and sex.