Table 3.

Associations Between Plasma Metabolite Levels and Incidence of T2DM in the MPP (N = 698) and the MDC-CC (N = 3423)

	MPP (N = 698)				MDC-CC (N = 3423)
	Model 1		Model 2		Model 1		Model 2
Metabolite	OR	P	OR	P	HR	P	HR	P
DMGU	1.67 (1.31–2.12)	3.6e-5	1.54 (1.20–1.99)	8.0e-4	1.28 (1.05–1.55)	0.012	1.28 (1.05–1.55)	0.014
7MG	1.49 (1.19–1.87)	5.9e-4	1.41 (1.12–1.79)	4.1e-3	1.25 (1.02–1.53)	0.035	1.24 (1.01–1.52)	0.043
HTML	1.50 (1.19–1.87)	5.1e-4	1.82 (1.25–2.65)	1.7e-3	1.41 (1.12–1.77)	3.0e-3	1.42 (1.13–1.79)	2.8e-3
Urea	1.23 (1.01–1.49)	0.036	1.19 (0.98–1.45)	0.072	1.24 (1.02–1.26)	0.024	1.14 (1.02–1.27)	0.020

ORs and HRs are expressed per SD increment of plasma metabolite and calculated from logistic regression models. Regression model 1 is adjusted for age, sex, fasting glucose, and BMI. Model 2 is additionally adjusted for systolic blood pressure and fasting levels of triglycerides, HDL, and LDL cholesterol.