Skip to main content
. 2019 Oct 22;2019(10):CD006611. doi: 10.1002/14651858.CD006611.pub5

Liao 2018.

Methods Study design: RCT
Country: China
Recruitment: via radio, bus billboards, online (e.g. websites, QQ, WeChat), newspapers, hospitals, and pharmacies in China
Study dates: 2016‐17
Participants Baseline characteristics (n = 1369)
  • Mean age: 38.1 years (SD 9.79)

  • Female: 5.4% (N = 74)

  • High school or lower education: 25.5% (N = 349)

  • FTND: 4.6 (SD 2.16)

  • White: not stated


Inclusion criteria: daily Chinese cigarette smokers. ≥ 18 years. Being able to read and write in Chinese. Owning a text‐capable cell phone and knowing how to text. Willing to make an attempt to quit smoking in the next month. Willing to provide informed consent to participate in the study.
Exclusion criteria: non‐smokers. < 18 years. Unable to read and write in Chinese.
Interventions High‐frequency text messaging (HFM): "Happy Quit" mobile phone‐based HFM for 12 weeks (3‐5 messages/day)
Low‐frequency text messaging (LFM): "Happy Quit" mobile phone‐based LFM for 12 weeks (3‐5 messages/week)
Control: 1 text message every week, thanking them for being in the study
Outcomes Definition of abstinence: biochemically confirmed continuous abstinence at 6 months
Funding source China Medical Board (CMB) Open Competition Program (Grant Number 15‐226)
Conflicts of interest None declared
Notes We compared HFM and LFM to control in the text messaging vs minimal SC support analysis, and compared HFM to LFM in the comparison of higher vs lower frequency text messaging
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Participants were randomly allocated using an independent telephone randomisation system that included a minimisation algorithm balancing for sex (male, female), age (18–34 years, > 34 years), educational level (years of education: < = 12 years, > 12 years), and FTND score (< = 5, > 5)
Allocation concealment (selection bias) Low risk Quote: "Participants, investigators, and research personnel were masked to treatment allocation"
Participants were randomly allocated using an independent telephone randomisation system
Blinding of outcome assessment (detection bias) 
 All outcomes Low risk Abstinence was biochemically verified
Incomplete outcome data (attrition bias) 
 All outcomes Low risk Quote: "By the end of the 24‐week trial period, the trial was completed by 83.2%, 74.6%, and 87.1% of participants in the HFM group, LFM group, and control group, respectively"