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Activation of TPO receptors by TPO or TPO receptor agonist and subsequent cascade associated with the activated pathway. GRB2 indicates growth factor receptor–bound protein 2; RAF, rapidly accelerated fibrosarcoma; SOS, Son of Sevenless; TPO, thrombopoietin; JAK, Janus Kinase; STAT, signal transducer and activator of transcription; MAPK, Mitogen -activated protein kinase.
