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. 2019 Oct 15;10:2288. doi: 10.3389/fimmu.2019.02288

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Copyright © 2019 Gu, Singh, Niyogi, Lamont, Wang, Lamont and Scott.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Phytocannabinoids alter the monocytic cytokine release profile in response to oral bacteria. Control and CBD (2 h) pre-exposed monocytes were stimulated, or not, with LPS or P. gingivalis and cytokine [(A) TNF, (B) IL-6, (C) IL-12 p40, (D) IL-8, (E) IL-10] release measured in 20 h cell-free supernatants by ELISA. Similar data was found upon F. alocis and T. denticola stimulation (data not shown). Similar phenomenon were also apparent with two the other phytocannabinoids tested, CBN and THC (data not shown). Data represent the mean ± SD of three biological replicates with paired data-points analyzed by t-test. */**/***p ≤ 0.05/0.01/0.001.