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. 2019 Oct 15;10:2288. doi: 10.3389/fimmu.2019.02288

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Copyright © 2019 Gu, Singh, Niyogi, Lamont, Wang, Lamont and Scott.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibition or silencing of PI3K abrogates CBD-mediated innate suppression. IL-6 (A,E) concentrations in 20 h cell-free supernatants were collected from primary human monocytes stimulated, or not, with LPS (0.1 μg/ml) in the presence or absence of CBD (A) with and without CB2 blockade by LY294002; or (E) with or without PI3K p110δ and/or p85α silencing using siRNA. Efficient PI3K knockdown was confirmed using Image J software (B–D). Similar data were obtained for IL-8 (data not shown). (A,E) Data represent the mean ± SD of three biological replicates. (B–D) Representative data are presented. */**/***p ≤ 0.05/0.01/0.001, compared to (A) LPS-stimulated control or (E) control siRNA, LPS-stimulated cells.