Value of the data •This data provides novel bioactivity for medicinally important plant and supplement drugs against oxidative stress. •Data proved the natural plant leaf extracts can effectively exert both oxidative stress resistance and anti-aging properties in the C. elegans model and may lead to new agents to benefit humans in the near future. •This data provides information to researchers of herbal medicine for the discovery of new therapeutic applications of compounds from G. zeylanicum. •This data will help in further research to identify bioactive molecules from the crude extracts that possessed antioxidant and anti-aging activities.