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. 2019 Jan 3;9(5):997–1007. doi: 10.1016/j.apsb.2018.12.011

Figure 3.

Fig. 3

Effect of the three putative YB-1 inhibitors on E2F1 promoter:luciferase reporter gene activity in cancer cell lines. Results shown here are representative of two independent experiments. (A) Effect of RUS0207-A006 on luciferase activity in A375 cells (IC50=73 µmol/L). Data shown are the mean of four replicates at each compound concentration within one experiment, with error bars indicating SEM. (B) Effect of RUS0202-G005 on luciferase activity in HCT116 cells (IC50=59 µmol/L). Data shown are the mean of three replicates at each compound concentration within one experiment, with error bars indicating SEM. (C) Effect of JK0395-B007 on luciferase activity in HCT116 cells (IC50=30 µmol/L). Data shown are the mean of three replicates at each compound concentration within one experiment, with error bars indicating SEM.