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. 2019 Jan 3;9(5):997–1007. doi: 10.1016/j.apsb.2018.12.011

Figure 5.

Fig. 5

Effects of the three putative YB-1 inhibitors on the growth of three cancer cell lines. Measurement of percentage viable cells, based on DNA content, was performed after treatment with a concentration range of each compound for 72 h. Data were normalized and plotted relative to DMSO-treated control (no compound) cells and expressed as means±standard error of at least three replicates within a single experiment. Results shown here are representative of two independent experiments. (A) A375 cells. RUS0207-A006 IC50=102 µmol/L, JK0395-B007 IC50=50 µmol/L. (B) HCT116 cells. RUS0207-A006 IC50=85 µmol/L, JK0395-B007 IC50=38 µmol/L. (C) MDA-MB-231 cells. RUS0207-A006 IC50=38 µmol/L, JK0395-B007 IC50=30 µmol/L.