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MCC1019 inhibit downstream effector proteins of PLK1. (A) Western blot analysis of BUBR1, p-AKT, p-FOXO1 and HIF-1α after treatment with different concentrations of MCC1019 for 24 h. Data represent relative expression intensity to β-actin, Error bars are ± SD of three independent experiments. (B) Diagram showing molecular effects of PLK1 inhibition on AKT signaling pathway that appeared in the study.
