Figure 3.

Mar-M suppress senescent cells expressing SASP. (A) Survival rate of PC3, RWPE1 treated with conditioned medium from senescent PC3/Doc cells. (B) Cytokine array blots for PC3/Doc cells that were treated with Mar-M or Doxo for 5 days. Cytokine levels of the supernatant were detected using cytokine array assay kit. (C) Cytokine levels of the supernatant were analyzed by heatmap. (D) The mRNA levels of cytokine and chemokine were detected with Q-PCR. Results are representative of three independent experiments. (E) Inflammation levels of different therapeutic method of breast carcinoma patients in TCGA. No therapy (NT), chemotherapy (CT), hormone therapy (HT), targeted molecular therapy (TMT), immunotherapy (IT), ancillary therapy (AT). (F) Overall survival plots of cytokine in TCGA patients that were treated with chemotherapy. Data are mean ± SD, ^*P < 0.05, ^**P < 0.01 and ^***P < 0.001.