Table 2.
Comparison of different optical coherence tomography analysis between patients and control eyes; mild cognitive impairment (MCI) patients and control eyes and Alzheimer's disease (AD) patients and controls
| Variables | Patients (N = 63) | Controls (N = 63) | P | MCI (N = 51) | Controls (N = 51) | P | AD (N = 12) | Controls (N = 12) | P |
|---|---|---|---|---|---|---|---|---|---|
| Average RNFL thickness | 97.7 (11,6) | 99.9 (8.2) | .004∗ | 93.7 (12.5) | 99.5 (8.1) | .005∗ | 99.4 (5.1) | 102.0 (9.3) | .482 |
| RNFL temporal | 66.5 (9.0) | 71.3 (10.2) | .028∗ | 65.9 (9.4) | 70.9 (10.7) | .050∗ | 70.0 (6.2) | 74.1 (5.8) | .312 |
| RNFL temporal-superior | 118.8 (16.6) | 127.4 (17.4) | .019∗ | 119.5 (16.3) | 127.3 (17.3) | .062 | 115.0 (19.0) | 128.3 (19.1) | .080 |
| RNFL temporal-inferior | 139.4 (20.8) | 149.8 (15.8) | .004∗ | 139.5 (22.0) | 149.0 (15.1) | .018∗ | 138.7 (10.4) | 153.7 (19.6) | .062 |
| RNFL nasal | 80.5 (17.8) | 81.7 (15.2) | .673 | 79.6 (18.3) | 80.1 (15.5) | .875 | 85.2 (14.4) | 90.4 (10.5) | .386 |
| RNFL nasal-superior | 111.3 (22.6) | 117.3 (25.8) | .201 | 108.9 (22.1) | 117.4 (25.5) | .090 | 124.3 (22.1) | 166.6 (20.1) | .571 |
| RNFL nasal-inferior | 105.5 (29.6) | 114.0 (18.0) | .062 | 109.7 (27.4) | 114.5 (16.8) | .275 | 83.0 (33.1) | 111.4 (24.9) | .100 |
| Average BMO-MRW | 290.3 (54.1) | 303.5 (54.6) | .263 | 281.9 (49.9) | 309.4 (54.9) | .027∗ | 326.8 (58.8) | 278.8 (47.3) | .106 |
| BMO-MRW temporal | 208.9 (49.9) | 203.3 (43.5) | .649 | 207.7 (52.8) | 205.4 (46.1) | .878 | 214.2 (27.6) | 193.8 (30.5) | .012∗ |
| BMO-MRW temporal-superior | 272.4 (64.2) | 291.9 (49.8) | .231 | 272.2 (70.1) | 295.2 (53.6) | .240 | 273.3 (28.8) | 276.8 (24.7) | .848 |
| BMO-MRW temporal-inferior | 286.2 (67.5) | 315.6 (64.6) | .131 | 277.6 (69.7) | 317.4 (64.9) | .091 | 324.6 (41.2) | 307.6 (68.8) | .267 |
| BMO-MRW nasal | 319.8 (65.5) | 325.2 (60.4) | .735 | 305.5 (55.2) | 327.3 (61.7) | .202 | 383.6 (74.9) | 315.5 (58.7) | .095 |
| BMO-MRW nasal-superior | 328.0 (75.0) | 347.2 (54.7) | .323 | 322.4 (74.9) | 348.1 (53.2) | .237 | 353.0 (76.3) | 343.3 (66.5) | .845 |
| BMO-MRW nasal-inferior | 348.3 (63.6) | 371.0 (59.1) | .138 | 342.2 (61.8) | 372.6 (61.3) | .089 | 375.6 (69.8) | 363.8 (52.0) | .657 |
| GCL superior | 47.5 (9.1) | 51.8 (5.6) | .006∗ | 48.3 (7.1) | 51.0 (5.5) | .057 | 44.3 (14.9) | 55.2 (5.4) | .050∗ |
| GCL inferior | 46.5 (9.8) | 50.9 (6.0) | .008∗ | 47.1 (8.5) | 50.2 (6.1) | .052 | 44.2 (14.4) | 53.7 (4.5) | .078 |
| GCL temporal | 41.7 (9.5) | 46.7 (5.8) | .002∗ | 42.2 (8.4) | 46.1 (6.1) | .015∗ | 39.6 (13.4) | 49.1 (4.3) | .074 |
| GCL nasal | 46.5 (9.3) | 50.5 (6.4) | .014∗ | 47.3 (7.8) | 50.1 (6.6) | .089 | 43.3 (14.2) | 52.7 (5.1) | .078 |
| IPL superior | 39.0 (4.3) | 41.1 (3.6) | .011∗ | 39.1 (4.4) | 40.5 (3.2) | .097 | 38.8 (4.1) | 44.0 (3.9) | .026∗ |
| IPL inferior | 38.6 (4.3) | 40.1 (3.7) | .066 | 38.5 (4.5) | 39.6 (3.7) | .268 | 38.8 (2.9) | 42.4 (2.5) | .007∗ |
| IPL temporal | 39.6 (4.1) | 40.8 (3.6) | .111 | 39.6 (4.1) | 40.3 (3.3) | .421 | 39.2 (3.8) | 43.0 (4.1) | .044∗ |
| IPL nasal | 39.8 (3.9) | 41.4 (3.5) | .025∗ | 39.7 (4.1) | 41.0 (3.4) | .138 | 39.7 (3.3) | 43.3 (3.0) | .009∗ |
| ONL superior | 63.4 (11.7) | 68.9 (10.7) | .010∗ | 63.3 (11.6) | 68.1 (11.3) | .048∗ | 63.5 (12.3) | 72.7 (5.8) | .058 |
| ONL inferior | 60.7 (15.2) | 63.5 (12.2) | .344 | 60.3 (14.5) | 63.5 (12.7) | .296 | 62.5 (18.4) | 63.1 (10.0) | .947 |
| ONL temporal | 69.4 (10.2) | 72.7 (10.3) | .072 | 68.6 (10.5) | 72.2 (10.8) | .100 | 72.9 (7.8) | 75.0 (6.7) | .442 |
| ONL nasal | 68.3 (15.3) | 72.2 (11.8) | .156 | 68.2 (15.1) | 72.2 (11.6) | .166 | 68.3 (16.9) | 72.0 (13.2) | .676 |
NOTE. Data for quantitative variables are shown as mean (standard deviation). Analysis was performed using paired Student's t-test for dependent samples.
Patients means mild cognitive impairment (MCI) and Alzheimer disease (AD) patients altogether.
Abbreviations: RNFL, retinal nerve fiber layer; GCL, ganglion cell layer; BMO-MRW, Bruch's membrane opening–minimum rim width; IPL. inner plexiform layer; ONL, outer nuclear layer.
∗
P value < .005.