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. 2019 Oct 3;5:515–523. doi: 10.1016/j.trci.2019.04.005

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© 2019 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 2 — Transition probabilities in the data sets. Shown are the mean (line), and standard deviation (cloud), of transition probabilities from CN to MCI (top row) and MCI to AD (bottom row). Probabilities are stratified by age, gender, and APOE ε4 carrier status (−/−, noncarrier, +/− homozyte, +/+, heterozyte). Abbreviations: CN, cognitively normal; MCI, mild cognitively impaired; AD, Alzheimer's disease; APOE, apolipoprotein E; ADNI, Alzheimer's Disease Neuroimaging Initiative; AIBL, Australian Imaging Biomarkers and Lifestyle; ANM, AddNeuroMed; FHS, the Framingham Heart Study; NACC, National Alzheimer's Coordinating Center.