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AhR ligand-mediated oxidation of S1PL in HMC-1 cells with or without ORMDL3 knockdown. a ROS generation, b S1PL activity, and c intracellular S1P level. d Western blotting analysis of oxidized S1PL in HMC-1 cells with Flag-S1PL expression. Intracellular S1P levels and S1PL activities in e HMC-1 and f A549 cells expressing S1PL wild-type or the C317A mutant. *p < 0.05. Data are representative of three independent experiments
